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New study to explore an intervention to help reduce weight in people with schizophrenia

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New study to explore an intervention to help reduce weight in people with schizophrenia


Published by University of Leicester Press Office for University of Leicester in Health and also in Education

Researchers from Leicester are involved in a project to investigate whether people with schizophrenia or first episode psychosis are able to reduce their weight through a structured education programme.

The project is led by Professor Richard Holt at the University of Southampton and involves researchers from the University of Leicester and University Hospitals of Leicester NHS Trust.

People with schizophrenia are two to three times more likely to be overweight or obese. As well as a range of adverse physical health consequences, such as diabetes and heart disease, weight gain may be an important factor that stops people taking their antipsychotic medication. This increases the risk of relapse of the schizophrenia and worse mental health.

However, if they can change their diet and exercise habits, their weight may reduce and quality of life improve.

The research, funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme, will develop an education approach, originally designed by the University of Leicester DESMOND team, to reduce the risk of type 2 diabetes, for people with schizophrenia. This will be examined in a randomised controlled STEPWISE (Structured lifestyle Education for People WIth SchizophrEnia) trial and compared to usual health and social care.

The programme will include four weekly sessions with clinicians and follow up sessions after three, six and nine months all focussing on diet and exercise.

The study will start recruiting participants from participating NHS Trusts in October 2014.

Professor Melanie Davies and Professor Kamlesh Khunti and their DESMOND Team, based at the University of Leicester and University Hospitals of Leicester NHS Trust, led the work in the UK and globally on Structured Education Programmes designed to meet the standards of education as outlined by NICE. The programme was initially developed for people with diabetes, however, there has been interest to develop such programmes using the DESMOND approach in other disease areas such as, for people following stoke, people with learning disabilities and the STEPWISE programme.

Richard Holt, Professor in Diabetes and Endocrinology at the University of Southampton, is leading the project in collaboration with co-investigators at the HTA 12/28/05 STEPWISE.

Universities of Sheffield and Leicester and mental health trusts across the UK. The study is sponsored by Sheffield Health and Social Care NHS Foundation Trust.

“We know people with severe mental illness die 10 to 20 years earlier than the general population. The commonest cause is from heart disease and being overweight or obese increases this risk. We want to develop a programme for use in the NHS that will help people with schizophrenia address the problem of obesity,” explains Professor Holt.

Dr David Shiers, a retired GP and collaborator on the project, said: “Given how weight gain can damage long term physical health as well as increase stigma it is incumbent on clinicians to seek more effective ways to offset such a serious adverse effect of the antipsychotic medication they prescribe”.


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